In September 2018, the Office of Refugee Resettlement (ORR) announced the allocation of over $8 million for a Refugee Support Services Youth Mentoring “Set-Aside,” dramatically increasing support for 15- to 24-year-old refugee and other ORR-eligible youth in 34 states. This information guide, designed for service providers implementing or applying for funding through the Set Aside, explains the existing evidence on youth mentoring and offers steps for designing an effective youth mentoring program that achieves the desired outcomes.